• Issue

    Drug Development Research: Volume 86, Issue 1

    February 2025
Previous Issue|Next Issue
Export Citation(s)

ISSUE INFORMATION

Free Access

Issue Information

  • First Published: 18 December 2024

RESEARCH ARTICLE

Full Access

Exosome-Shuttled METTL14 From AML-Derived Mesenchymal Stem Cells Promotes the Proliferation and Radioresistance in AML Cells by Stabilizing ROCK1 Expression via an m6A-IGF2BP3-Dependent Mechanism

Cheng Wang,  Rui Song,  Jinjin Yuan,  Ge Hou,  A lan Chu,  Yangyang Huang,  Chenhu Xiao,  Ting Chai,  Chen Sun,  Zongwen Liu, 
  • First Published: 18 December 2024

REVIEW ARTICLE

Full Access

Structural Diversity and Mutational Challenges of Toll-Like Receptor 4 Antagonists as Inflammatory Pathway Blocker

S. K. Batin Rahaman,  Sandip K. Nandi,  Sudip Kumar Mandal,  Utsab Debnath, 
  • First Published: 18 December 2024

RESEARCH ARTICLE

Full Access

Naringenin Inhibits Ferroptosis in Renal Tubular Epithelial Cells of Diabetic Nephropathy Through SIRT1/FOXO3a Signaling Pathway

Yi Zhou,  Tianchi Hu,  Huarong Zeng,  Lin Lin,  Huan Xie,  Rong Lin,  Mengya Huang, 
  • First Published: 12 January 2025
Full Access

Design, Synthesis, Biological Evaluation and Molecular Docking Study of New 1,3,4-Thiadiazole-Based Compounds as EGFR Inhibitors

Marwa I. Serag,  Samar S. Tawfik,  Hassan M. Eisa,  Sahar M. I. Badr, 
  • First Published: 24 December 2024
Full Access

Phthalazine Derivatives as VEGFR-2 Inhibitors: Docking, ADMET, Synthesis, Design, Anticancer Evaluations, and Apoptosis Inducers

Hatem Hussein Bayoumi,  Mohamed-Kamal Ibrahim,  Mohammed A. Dahab,  Fathalla Khedr,  Khaled El-Adl, 
  • First Published: 24 December 2024

REVIEW ARTICLE

Full Access

Orthoallosteric EGFR-TKIs: A New Paradigm in NSCLC Treatment Strategy Targeting the C797S Mutation

Iqrar Ahmad,  Harun M. Patel, 
  • First Published: 25 December 2024

RESEARCH ARTICLE

Full Access

Sulfamethizole Attenuates Pentylenetetrazole-Induced Seizures in Mice via mTOR Inhibition

Lazari Kambli,  Dezaree Raut,  Lokesh Kumar Bhatt, 
  • First Published: 26 December 2024
Full Access

Reduction-Responsive RGD-Docetaxel Conjugate: Synthesis, In Vitro Drug Release and In Vitro Antitumor Activity

Qingqing Li,  Yufeng Liu,  Yilin Cheng,  Huaibao Cao,  Kunda Du,  Tianyu Zhu,  Defeng Xu,  Hang Hu, 
  • First Published: 25 December 2024
Open Access

An Inducible Neural Stem Progenitor Cell Model for Testing Therapeutic Interventions Against Neurodegeneration FENIB

Alessandro Giustini,  Alice Maiocchi,  Ilaria Serangeli,  Martina Pedrini,  Anna Quintiliani,  Valentina Sabato,  Francesca Bonato,  Pierfausto Seneci,  Giuseppe Lupo,  Daniele Passarella,  Elena Miranda, 
  • First Published: 03 January 2025
Full Access

Bioinformatics Exploration of the Therapeutic Potential of Lotus Seed Compounds in Multiple Sclerosis: A Network Analysis of c-Jun Pathway

Rapuru Rushendran,  Ankul Singh S.,  Rukaiah Fatma Begum,  Vellapandian Chitra,  Nemat Ali,  Bhupendra G. Prajapati, 
  • First Published: 05 January 2025

REVIEW ARTICLE

Full Access

Current Strategies and Future Dimensions in the Development of KRAS Inhibitors for Targeted Anticancer Therapy

Laura D'Alessio-Sands,  Joshua Gaynier,  Victoria Michel-Milian,  Ayodeji A. Agbowuro,  Christopher M. Brackett, 
  • First Published: 12 January 2025

RESEARCH ARTICLE

Full Access

A Real-World Disproportionality Analysis of Histamine H2-Receptors Antagonists (Famotidine): A Pharmacovigilance Study Based on Spontaneous Reports in the FDA Adverse Event Reporting System

Dongdong Zhang,  Ying Cai,  Yixin Sun,  Peiji Zeng,  Wei Wang,  Wenhui Wang,  Xiaohua Jiang,  Yifan Lian, 
  • First Published: 16 January 2025
Full Access

Downregulation of LncRNA CCAT1 Enhances Chemosensitivity in Cisplatin-Resistant Gastric Cancer Cells

Qiong Wu,  Chenglou Zhu,  Tiantian Zhao,  Tianxiang Liu,  Mingxu Da, 
  • First Published: 20 January 2025
Full Access

Disruption of the FOXM1 Regulatory Region Inhibits Tumor Progression in Ovarian Cancer by CRISPR-Cas9

Yujie Chen,  Yingzhuo Xue,  Qiuwen Jiang,  Yunfeng Jin,  Weiguan Chen,  Minhui Hua, 
  • First Published: 20 January 2025
Full Access

Isoliquiritigenin Protects Against Diabetic Nephropathy in db/db Mice by Inhibiting Advanced Glycation End Product–Receptor for Advanced Glycation End Product Axis

Qiwen Shi,  Tao Zhou,  Wenjun Hou,  Yuqi Zhou,  Shufen Deng,  Ying Song, 
  • First Published: 27 January 2025
Full Access

Investigating the Impact of B Cell-Related Genes on Colorectal Cancer Immunosuppressive Environment and Immunotherapy Evasion

Haixia Wu,  Yilin Yu,  Zhiping Wang,  Shiji Wu,  Lingdong Shao,  Liang Hong,  Jianjian Qiu,  Xueqing Zhang,  Junxin Wu, 
  • First Published: 27 January 2025
Full Access

Antileishmanial and Antitrypanosomal Trends of Synthetic Tetralone Derivatives

Abdulsalam A. M. Alkhaldi,  Harry P. de Koning,  Syed Nasir Abbas Bukhari, 
  • First Published: 29 January 2025
Full Access

Andrographolide Mitigates Cisplatin Resistance by Inhibiting SPP1 Regulated NF-kB/iNOS/COX-2 and PI3K/AKT Pathway in Cisplatin Resistant Cervical Carcinoma Cells

Akbar Pasha,  Doneti Ravinder,  Smita C. Pawar, 
  • First Published: 30 January 2025
Full Access

Design, Synthesis, Docking Studies, and Investigation of Dual EGFR/VEGFR-2 Inhibitory Potentials of New Pyrazole and Pyrazolopyridine Derivatives

Shimaa M. Alhamaky,  Nadia A. Khalil,  Amr K. A. Bass,  Nada Osama,  Marwa S. A. Hassan, 
  • First Published: 05 February 2025

REVIEW ARTICLE

Full Access

Experimentation of Heterocycles (2013-22) as Potent Pharmacophores in Drug Design of Multiple Sclerosis

Atukuri Dorababu, 
  • First Published: 05 February 2025

RESEARCH ARTICLE

Open Access

Discovery of Hydrazine Clubbed Thiazoles as Potential Antidiabetic Agents: Synthesis, Biological Evaluation, and Molecular Docking Studies

Betül Kaya,  Hakan Tahtacı,  Bilge Çiftçi,  Hatice Esra Duran,  Adem Necip,  Mesut Işık,  Şükrü Beydemir, 
  • First Published: 05 February 2025
Full Access

Design, Synthesis and Molecular Docking of New Thieno[2,3‑d]Pyrimidin-4-One Derivatives as Dual EGFR and FGFR Inhibitors

Sara Sultan,  Samar S. Tawfik,  Khalid B. Selim,  Magda N.A. Nasr, 
  • First Published: 06 February 2025

RETRACTION

Free Access

RETRACTION: to “Oleanolic Acid Reduces Oxidative Stress and Neuronal Apoptosis After Experimental Subarachnoid Hemorrhage by Regulating Nrf2/HO-1 Pathway”

  • First Published: 06 February 2025

REVIEW ARTICLE

Full Access

Unraveling the Role of Repurposed Drugs in the Treatment of Acne: Success so Far and the Road Ahead

Popat S. Kumbhar,  Vikas Kamble,  Kaustubh Ajit Kolekar,  Sukriti Vishwas,  Pranav Kumbhar,  Kalpana S. Patil,  Gaurav Gupta,  Pankaj M. Kharabe,  Manisha Singh,  Shailendra Gurav,  Dinesh Kumar Chellappan,  Sachin Kumar Singh,  Kamal Dua,  John Disouza,  Vandana Patravale, 
  • First Published: 10 February 2025

RESEARCH ARTICLE

Full Access

Assessment of Antidiarrheal Effect of Oleuropein Through µ-Oopioid Receptor Interaction Pathway: In Vivo and in Silico Studies

Nishat Jahan,  Manoj Mandal,  Imam Hossen Rakib,  Md. Sakib Al Hasan,  Emon Mia,  Md. Arif Hossain,  Noshin Tasnim Yana,  Siddique Akber Ansari,  Mehedi Hasan Bappi,  Ali Mohamod Wasaf Hasan,  Md Abu Sayeed,  Muhammad Torequl Islam, 
  • First Published: 09 February 2025
Full Access

Reviewing on AI-Designed Antibiotic Targeting Drug-Resistant Superbugs by Emphasizing Mechanisms of Action

Zafer Yönden,  Samira Reshadi,  Ahmad Farrokh Hayati,  Mohammad Hossein Hooshiar,  Sholeh Ghasemi,  Hakan Yönden,  Amin Daemi, 
  • First Published: 11 February 2025
Full Access

Unraveling the Curcumin's Molecular Targets and Its Potential in Suppressing Skin Inflammation Using Network Pharmacology and In Vitro Studies

Anjana Sureshbabu,  Elena Smirnova,  Do Thi Cat Tuong,  Sangeetha Vinod,  Sungyeon Chin,  Mohammad Moniruzzaman,  Kalaiselvi Senthil,  Dong I. Lee,  Karthikeyan Adhimoolam,  Taesun Min, 
  • First Published: 12 February 2025
Full Access

Exosomal ALKBH5 Alleviates Vascular Calcification by Suppressing Cell Apoptosis via m6A-Modified GSDME

Guian Xu,  Qingman Li,  Lijie Zhu,  Tingjie Yang,  Yapan Yang,  Honghui Yang, 
  • First Published: 14 February 2025
Full Access

In Vitro and In Silico Assessment of Antileishmanial Potential of Novel Tri- and Penta-Valent Antimony Complexes With Phenolic Ligands

Syeda Aaliya Shehzadi,  Faiz Ahmed,  Arshad Islam,  Zeshan Ahmed,  Khizar Abdullah,  Farhan Younas,  Ali Haider,  Muhammad Tariq,  Ahmed Noureldeen,  Bander Albogami,  Hadeer Darwish,  Fatemah Enad M. Alajmi, 
  • First Published: 12 February 2025